Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction properties

Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction properties

Considerable effort has been devoted to developing adeno-associated virus (AAV)-based vectors for gene therapy in cystic fibrosis (CF). As a result of directed evolution and capsid shuffling technology, AAV capsids are available with widespread tropism for airway epithelial cells. For example, AAV2....

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Bibliographic Details
Main Authors: Ashley L. Cooney, Christian M. Brommel, Soumba Traore, Gregory A. Newby, David R. Liu, Paul B. McCray, Patrick L. Sinn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Genome Editing
Subjects:
adeno-associated virus capsid
gene therapy
cystic fibrosis
airway epithelia
base editing
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2023.1271813/full

Internet

https://www.frontiersin.org/articles/10.3389/fgeed.2023.1271813/full

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