HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells

HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells

Histone deacetylase 6 (HDAC6) is an emerging therapeutic target that is overexpressed in glioblastoma when compared to other HDACs. HDAC6 catalyzes the deacetylation of alpha-tubulin and mediates the disassembly of primary cilia, a process required for cell cycle progression. HDAC6 inhibition disrup...

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Bibliographic Details
Main Authors: Ping Shi, Lan B. Hoang-Minh, Jia Tian, Alice Cheng, Reemsha Basrai, Neil Kalaria, Joseph J. Lebowitz, Habibeh Khoshbouei, Loic P. Deleyrolle, Matthew R. Sarkisian
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
histone deacetylase 6
primary cilium
glioblastoma
ARL13B
alpha-tubulin
Online Access:https://www.mdpi.com/2072-6694/13/7/1644

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https://www.mdpi.com/2072-6694/13/7/1644

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