In Vitro Low-Bortezomib Doses Induce Apoptosis and Independently Decrease the Activities of Glutathione S-Transferase and Glutathione Peroxidase in Multiple Myeloma, Taking into Account the <i>GSTT1</i> and <i>GSTM1</i> Gene Variants

In Vitro Low-Bortezomib Doses Induce Apoptosis and Independently Decrease the Activities of Glutathione S-Transferase and Glutathione Peroxidase in Multiple Myeloma, Taking into Account the <i>GSTT1</i> and <i>GSTM1</i> Gene Variants

Background: Multiple myeloma (MM) is a malignancy derived from plasma cells. Bortezomib affects the concentration of reduced glutathione (GSH) and the activity of glutathione enzymes. The aim of our study was to analyze deletion (null/present) variants of <i>GSTT1</i> and <i>GSTM1&...

Full description

Bibliographic Details
Main Authors: Szymon Zmorzynski, Sylwia Popek-Marciniec, Beata Biernacka, Aneta Szudy-Szczyrek, Sylwia Chocholska, Wojciech Styk, Joanna Czerwik-Marcinkowska, Grazyna Swiderska-Kolacz
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Genes
Subjects:
apoptosis
bortezomib
glutathione peroxidase
glutathione S-transferase
glutathione reductase
multiple myeloma
Online Access:https://www.mdpi.com/2073-4425/15/3/387

Internet

https://www.mdpi.com/2073-4425/15/3/387

Similar Items