Development of Bedaquiline-Loaded SNEDDS Using Quality by Design (QbD) Approach to Improve Biopharmaceutical Attributes for the Management of Multidrug-Resistant Tuberculosis (MDR-TB)

Development of Bedaquiline-Loaded SNEDDS Using Quality by Design (QbD) Approach to Improve Biopharmaceutical Attributes for the Management of Multidrug-Resistant Tuberculosis (MDR-TB)

<b>Background:</b> The ever-growing emergence of antibiotic resistance associated with tuberculosis (TB) has become a global challenge. In 2012, the USFDA gave expedited approval to bedaquiline (BDQ) as a new treatment for drug-resistant TB in adults when no other viable options are avai...

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Bibliographic Details
Main Authors: Rao Nargis Jahan, Zafar Khan, Md. Sayeed Akhtar, Mohd Danish Ansari, Pavitra Solanki, Farhan J. Ahmad, Mohd Aqil, Yasmin Sultana
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antibiotics
Subjects:
bedaquiline
oral bioavailability
solubility
quality by design (QbD)
pseudo-ternary
self-nanoemulsifying drug delivery systems (SNEDDS)
Online Access:https://www.mdpi.com/2079-6382/12/10/1510

Internet

https://www.mdpi.com/2079-6382/12/10/1510

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