The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.

Bibliographic Details
Main Authors: Yuanming Xu, Fang Zhao, Quan Qiu, Kun Chen, Juncheng Wei, Qingfei Kong, Beixue Gao, Johanna Melo-Cardenas, Bin Zhang, Jinping Zhang, Jianxun Song, Donna D. Zhang, Jianing Zhang, Yunping Fan, Huabin Li, Deyu Fang
Format: Article
Language:English
Published: Nature Portfolio 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12073

Internet

https://doi.org/10.1038/ncomms12073

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