SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential

SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential

Low back pain (LBP) is a pervasive global health concern, primarily associated with intervertebral disc (IVD) degeneration. Although oxidative stress has been shown to contribute to IVD degeneration, the underlying mechanisms remain undetermined. This study aimed to unravel the role of superoxide di...

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Bibliographic Details
Main Authors: Shota Tamagawa, Daisuke Sakai, Hidetoshi Nojiri, Yoshihiko Nakamura, Takayuki Warita, Erika Matsushita, Jordy Schol, Hazuki Soma, Shota Ogasawara, Daiki Munesada, Masato Koike, Takahiko Shimizu, Masato Sato, Muneaki Ishijima, Masahiko Watanabe
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Redox Biology
Subjects:
Low back pain
Intervertebral disc degeneration
Oxidative stress
Superoxide dismutase 2
Aging
Mechanical stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000673

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http://www.sciencedirect.com/science/article/pii/S2213231724000673

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