Intracellular pH affects mitochondrial homeostasis in cultured human corneal endothelial cells prepared for cell injection therapy

Abstract This study aimed to uncover the mechanism responsible for the clinical efficacy of cell injection therapy with fully differentiated cultured cells. Analysis of polarized expression of ion transporters on cultured human corneal endothelial cells (CECs) subpopulations (SPs) was performed. The...

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Bibliographic Details
Main Authors: Hideto Deguchi, Tomoko Yamashita, Nao Hiramoto, Yohei Otsuki, Atsushi Mukai, Morio Ueno, Chie Sotozono, Shigeru Kinoshita, Junji Hamuro
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-10176-1