The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

Summary: Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis. Given the importance of microRNAs (miRNAs) in regulating cellular plasticity, we performed an unbiased screening and identified the miR-200 famil...

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Bibliographic Details
Main Authors: Phillip M. Shelton, Angeles Duran, Yuki Nakanishi, Miguel Reina-Campos, Hiroaki Kasashima, Victoria Llado, Li Ma, Alex Campos, Damián García-Olmo, Mariano García-Arranz, Dolores C. García-Olmo, Susana Olmedillas-López, Javier F. Caceres, Maria T. Diaz-Meco, Jorge Moscat
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718304947

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http://www.sciencedirect.com/science/article/pii/S2211124718304947

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