HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC)

HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC)

Abstract Background Hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) is heterogeneous and frequently contains multifocal tumors, but how the multifocal tumors relate to each other in terms of HBV integration and other genomic patterns is not clear. Methods To interrogate heterogeneity...

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Bibliographic Details
Main Authors: Wenhui Wang, Yan Chen, Liang Wu, Yi Zhang, Seungyeul Yoo, Quan Chen, Shiping Liu, Yong Hou, Xiao-ping Chen, Qian Chen, Jun Zhu
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Medical Genomics
Subjects:
Hepatocellular carcinoma
Hepatitis B virus integration
Enriched single cell sequencing
Copy number variation
Clonal evolution
Online Access:https://doi.org/10.1186/s12920-022-01264-2

Internet

https://doi.org/10.1186/s12920-022-01264-2

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