Altered galectin-3 distribution and migratory function in the pre-diabetic non-obese diabetic mouse thymus

Altered galectin-3 distribution and migratory function in the pre-diabetic non-obese diabetic mouse thymus

Galectin-3 is an endogenous lectin which binds mainly to β-galactosides on the cell surface and extracellular matrix (ECM) glycoproteins. In the thymus, this lectin is constitutively expressed, being involved in thymocyte adhesion, migration, and death. Galectin-3 has been related to type 1 diabetes...

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Bibliographic Details
Main Authors: Tiago Dutra Pereira Ramos, Ana Lucia Marques Ventura, Julia Pereira Lemos, Roger Chammas, Wilson Savino, Carla Eponina Carvalho-Pinto, Daniella Arêas Mendes-da-Cruz, Déa Maria Serra Villa-Verde
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Endocrinology
Subjects:
thymus
galectin-3
type 1 diabetes
NOD mice
extracellular matrix
thymocyte migration
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1200935/full

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https://www.frontiersin.org/articles/10.3389/fendo.2024.1200935/full

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