The Role of p53 Dysfunction in Colorectal Cancer and Its Implication for Therapy

The Role of p53 Dysfunction in Colorectal Cancer and Its Implication for Therapy

Colorectal cancer (CRC) is one of the most common and fatal cancers worldwide. The carcinogenesis of CRC is based on a stepwise accumulation of mutations, leading either to an activation of oncogenes or a deactivation of suppressor genes. The loss of genetic stability triggers activation of proto-on...

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Bibliographic Details
Main Authors: Maurice Michel, Leonard Kaps, Annett Maderer, Peter R. Galle, Markus Moehler
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
colorectal cancer
p53
systemic therapy
immunotherapy
tumor microenvironment (TME)
cancer-associated fibroblasts
Online Access:https://www.mdpi.com/2072-6694/13/10/2296

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https://www.mdpi.com/2072-6694/13/10/2296

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