Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants

Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants

Abstract Background Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in PD pathogenesis remain major challenges. To identif...

Full description

Bibliographic Details
Main Authors: Rui Chen, Jiewei Liu, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yong-Gang Yao, Xiao Xiao, Ming Li, Xiong-Jian Luo
Format: Article
Language:English
Published: BMC 2022-02-01
Series:BMC Medicine
Subjects:
Parkinson’s disease (PD)
Genome-wide association studies (GWASs)
Single-nucleotide polymorphisms (SNPs)
Functional genomics
Transcription factor (TF) binding
Regulatory mechanisms
Online Access:https://doi.org/10.1186/s12916-022-02264-w

Internet

https://doi.org/10.1186/s12916-022-02264-w

Similar Items