The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury

The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury

Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disease characterized by scar formation and respiratory insufficiency, which progressively leads to death. Pulmonary hypertension (PH) is a common complication of IPF that negatively impacts clinical outcomes, and has been classified as Group III...

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Bibliographic Details
Main Authors: Anandharajan Rathinasabapathy, Alana Horowitz, Kelsey Horton, Ashok Kumar, Santhi Gladson, Thomas Unger, Diana Martinez, Gaurav Bedse, James West, Mohan K. Raizada, Ulrike M. Steckelings, Colin Sumners, Michael J. Katovich, Vinayak Shenoy
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
pulmonary fibrosis
pulmonary hypertension
C21
AT2 receptor
bleomycin
rats
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00180/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00180/full

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