Epigenetics in Canine Mammary Tumors: Upregulation of miR-18a and miR-18b Oncogenes Is Associated with Decreased <i>ERS1</i> Target mRNA Expression and ERα Immunoexpression in Highly Proliferating Carcinomas

Epigenetics in Canine Mammary Tumors: Upregulation of miR-18a and miR-18b Oncogenes Is Associated with Decreased <i>ERS1</i> Target mRNA Expression and ERα Immunoexpression in Highly Proliferating Carcinomas

The expression of miRNAs is one of the main epigenetic mechanisms responsible for the regulation of gene expression in mammals, and in cancer, miRNAs participate by regulating the expression of protein-coding cancer-associated genes. In canine mammary tumors (CMTs), the <i>ESR1</i> gene...

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Bibliographic Details
Main Authors: Jessica Maria Abbate, Francesca Arfuso, Kristian Riolo, Fabiano Capparucci, Barbara Brunetti, Giovanni Lanteri
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Animals
Subjects:
canine mammary tumors
epigenetics
ERα
<i>ESR1</i>
miR-18a
miR-18b
Online Access:https://www.mdpi.com/2076-2615/13/6/1086

Internet

https://www.mdpi.com/2076-2615/13/6/1086

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