Synthesis, Characterization and Cytotoxic Evaluation of New Pyrrolo[1,2-<i>b</i>]pyridazines Obtained via Mesoionic Oxazolo-Pyridazinones

Synthesis, Characterization and Cytotoxic Evaluation of New Pyrrolo[1,2-<i>b</i>]pyridazines Obtained via Mesoionic Oxazolo-Pyridazinones

New pyrrolo[1,2-<i>b</i>]pyridazines were synthesized by 3 + 2 cycloaddition reaction between mesoionic oxazolo-pyridazinones and methyl/ethyl propiolate. The mesoionic compounds were generated in situ by action of acetic anhydride on 3(2<i>H</i>)pyridazinone acids obtained f...

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Bibliographic Details
Main Authors: Beatrice-Cristina Ivan, Stefania-Felicia Barbuceanu, Camelia Mia Hotnog, Octavian Tudorel Olaru, Adriana Iuliana Anghel, Robert Viorel Ancuceanu, Mirela Antonela Mihaila, Lorelei Irina Brasoveanu, Sergiu Shova, Constantin Draghici, George Mihai Nitulescu, Florea Dumitrascu
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
pyrrolo[1,2-<i>b</i>]pyridazines
mesoionic oxazolo-pyridazinones
dipolarophile alkynes
3 + 2 cycloaddition
X-ray diffraction
cytotoxicity
Online Access:https://www.mdpi.com/1422-0067/24/14/11642

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https://www.mdpi.com/1422-0067/24/14/11642

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