CERE-120 Prevents Irradiation-Induced Hypofunction and Restores Immune Homeostasis in Porcine Salivary Glands

CERE-120 Prevents Irradiation-Induced Hypofunction and Restores Immune Homeostasis in Porcine Salivary Glands

Salivary gland hypofunction causes significant morbidity and loss of quality of life for head and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet therapeutic need. We used an adeno-associated virus serotype 2 (AAV2) vector expressing the human neurotrophic factor...

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Bibliographic Details
Main Authors: Isabelle M.A. Lombaert, Vaishali N. Patel, Christina E. Jones, Derrick C. Villier, Ashley E. Canada, Matthew R. Moore, Elsa Berenstein, Changyu Zheng, Corinne M. Goldsmith, John A. Chorini, Daniel Martin, Lee Zourelias, Mark G. Trombetta, Paul C. Edwards, Kathleen Meyer, Dale Ando, Michael J. Passineau, Matthew P. Hoffman
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapy
AAV-neurturin
salivary gland
irradiation damage
salivary hypofunction
head and neck cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301650

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http://www.sciencedirect.com/science/article/pii/S2329050120301650

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