Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.

Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.

The function of Sprouty2 (Spry2) in T cells is unknown. Using 2 different (inducible and T cell-targeted) knockout mouse strains, we found that Spry2 positively regulated extracellular signal-regulated kinase 1/2 (ERK1/2) signaling by modulating the activity of LCK. Spry2-/- CD4+ T cells were unable...

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Bibliographic Details
Main Authors: Anand Sripada, Kapil Sirohi, Lidia Michalec, Lei Guo, Jerome T McKay, Sangya Yadav, Mukesh Verma, James Good, Donald Rollins, Magdalena M Gorska, Rafeul Alam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001063

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https://doi.org/10.1371/journal.pbio.3001063

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