The CtIP-CtBP1/2-HDAC1-AP1 transcriptional complex is required for the transrepression of DNA damage modulators in the pathogenesis of osteosarcoma

The CtIP-CtBP1/2-HDAC1-AP1 transcriptional complex is required for the transrepression of DNA damage modulators in the pathogenesis of osteosarcoma

Most tumors, including osteosarcomas, have deficiencies in DNA damage repair. However, the regulatory mechanisms underlying dysregulation of DNA damage repair genes are still being investigated. In this study, we reveal that C-terminal binding protein (CtBP) interacting protein (CtIP) couples with t...

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Bibliographic Details
Main Authors: Xun Chen, Qian Zhang, Xiaoqian Dang, Jinzhu Fan, Tao Song, Zhong Li, Ning Duan, Wentao Zhang
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Translational Oncology
Subjects:
CtIP
CtBP1
CtBP2
AP1, DNA damage
Osteosarcoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322000882

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http://www.sciencedirect.com/science/article/pii/S1936523322000882

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