Pre-activation of autophagy impacts response to olaparib in prostate cancer cells
Pre-activation of autophagy mediates resistance to olaparib by decreasing nuclear SQSTM1/p62, which increases homologous recombination-mediated repair through filamin A expression and BRCA1/Rad51 recruitment.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03210-5 |