Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences

Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences

Abstract Background The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients. ASD prevalence is higher in boys, but increasing evidence suggests underdiagnosis and undertreatme...

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Bibliographic Details
Main Authors: Simona Scheggi, Francesca Guzzi, Giulia Braccagni, Maria Graziella De Montis, Marco Parenti, Carla Gambarana
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Molecular Autism
Subjects:
Autism spectrum disorder
Reward
Dopamine
Valproic acid
Animal models
Online Access:http://link.springer.com/article/10.1186/s13229-020-00358-x

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http://link.springer.com/article/10.1186/s13229-020-00358-x

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