A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids

A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids

With an aim to develop more effective and affordable anticancer agents possessing a unique mechanism of action, we designed and synthesized derivatives of spirooxindole-pyrrolidine heterocyclic hybrids in good yields through a one-pot three-component (3+2) cycloaddition strategy. The synthesized com...

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Bibliographic Details
Main Authors: Raju Suresh Kumar, Dhaifallah M. Al-thamili, Abdulrahman I. Almansour, Natarajan Arumugam, Faruq Mohammad
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
multicomponent reaction
functionalized spirooxindole-pyrrolidine hybrids
anticancer activity
controlled cell death
apoptosis
ROS generation
Online Access:https://www.mdpi.com/1420-3049/25/23/5581

Internet

https://www.mdpi.com/1420-3049/25/23/5581

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