AMBN mutations causing hypoplastic amelogenesis imperfecta and Ambn knockout‐NLS‐lacZ knockin mice exhibiting failed amelogenesis and Ambn tissue‐specificity

AMBN mutations causing hypoplastic amelogenesis imperfecta and Ambn knockout‐NLS‐lacZ knockin mice exhibiting failed amelogenesis and Ambn tissue‐specificity

Abstract Background Ameloblastin (AMBN) is a secreted matrix protein that is critical for the formation of dental enamel and is enamel‐specific with respect to its essential functions. Biallelic AMBN defects cause non‐syndromic autosomal recessive amelogenesis imperfecta. Homozygous Ambn mutant mice...

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Bibliographic Details
Main Authors: Tian Liang, Yuanyuan Hu, Charles E. Smith, Amelia S Richardson, Hong Zhang, Jie Yang, Brent Lin, Shih‐Kai Wang, Jung‐Wook Kim, Yong‐Hee Chun, James P. Simmer, Jan C.‐C. Hu
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
Ambn ‐/‐ Amelx ‐/-
amelin
ameloblastin
amelogenin
dental enamel formation
matrix proteins
Online Access:https://doi.org/10.1002/mgg3.929

Internet

https://doi.org/10.1002/mgg3.929

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