Inhibition of intracellular proton-sensitive Ca2+-permeable TRPV3 channels protects against ischemic brain injury

Inhibition of intracellular proton-sensitive Ca2+-permeable TRPV3 channels protects against ischemic brain injury

Ischemic brain stroke is pathologically characterized by tissue acidosis, sustained calcium entry and progressive cell death. Previous studies focusing on antagonizing N-methyl-d-aspartate (NMDA) receptors have failed to translate any clinical benefits, suggesting a non-NMDA mechanism involved in th...

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Bibliographic Details
Main Authors: Xiaoling Chen, Jingliang Zhang, KeWei Wang
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
TRPV3
Ca2+ influx
Acidosis
Cerebral ischemia/reperfusion injury
Excitotoxicity
Neural excitability
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522000132

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http://www.sciencedirect.com/science/article/pii/S2211383522000132

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