Stability depends on positive autoregulation in Boolean gene regulatory networks.

Network motifs have been identified as building blocks of regulatory networks, including gene regulatory networks (GRNs). The most basic motif, autoregulation, has been associated with bistability (when positive) and with homeostasis and robustness to noise (when negative), but its general importanc...

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Bibliographic Details
Main Authors: Ricardo Pinho, Victor Garcia, Manuel Irimia, Marcus W Feldman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4222607?pdf=render