<it>In vivo </it>antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera

<p>Abstract</p> <p>Background</p> <p>An important limiting factor in the development of centrally acting pharmaceuticals is the blood-brain barrier (BBB). Transport of therapeutic peptides through this highly protective physiological barrier remains a challenge for pept...

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Podrobná bibliografie
Hlavní autoři: Guillemyn Karel, Kleczkowska Patrycja, Novoa Alexandre, Vandormael Bart, Van den Eynde Isabelle, Kosson Piotr, Asim Muhammad, Schiller Peter W, Spetea Mariana, Lipkowski Andrzej W, Tourwé Dirk, Ballet Steven
Médium: Článek
Jazyk:English
Vydáno: BMC 2012-01-01
Edice:Molecular Brain
Témata:
On-line přístup:http://www.molecularbrain.com/content/5/1/4