Sphingosine Kinase-1 Is Overexpressed and Correlates with Hypoxia in Osteosarcoma: Relationship with Clinicopathological Parameters

Sphingosine Kinase-1 Is Overexpressed and Correlates with Hypoxia in Osteosarcoma: Relationship with Clinicopathological Parameters

The Sphingosine kinase-1/Sphingosine 1-Phosphate (SphK1/S1P) signaling pathway is overexpressed in various cancers, and is instrumental for the adaptation to hypoxia in a number of solid tumor models, but no data are available in osteosarcoma. Here we report that SphK1 and the S1P<sub>1</su...

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Bibliographic Details
Main Authors: Anne Gomez-Brouchet, Claire Illac, Adeline Ledoux, Pierre-Yves Fortin, Sandra de Barros, Clémentine Vabre, Fabien Despas, Sophie Peries, Christelle Casaroli, Corinne Bouvier, Sébastien Aubert, Gonzague de Pinieux, Frédérique Larousserie, Louise Galmiche, Franck Talmont, Stuart Pitson, Marie-Lise Maddelein, Olivier Cuvillier
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
FTY720
fingolimod
sphingosine kinase
S1P<sub>1</sub>
osteosarcoma
HIF
Online Access:https://www.mdpi.com/2072-6694/14/3/499

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https://www.mdpi.com/2072-6694/14/3/499

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