Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.

Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.

Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating sister chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi....

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Bibliographic Details
Main Authors: Vlad C Seitan, Peter Banks, Steve Laval, Nazia A Majid, Dale Dorsett, Amer Rana, Jim Smith, Alex Bateman, Sanja Krpic, Arnd Hostert, Robert A Rollins, Hediye Erdjument-Bromage, Paul Tempst, Claire Y Benard, Siegfried Hekimi, Sarah F Newbury, Tom Strachan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0040242

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https://doi.org/10.1371/journal.pbio.0040242

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