Examining the Effect of Kindlin-3 Binding Site Mutation on LFA-1-ICAM-1 Bonds by Force Measuring Optical Tweezers

Examining the Effect of Kindlin-3 Binding Site Mutation on LFA-1-ICAM-1 Bonds by Force Measuring Optical Tweezers

Integrins in effector T cells are crucial for cell adhesion and play a central role in cell-mediated immunity. Leukocyte adhesion deficiency (LAD) type III, a genetic condition that can cause death in early childhood, highlights the importance of integrin/kindlin interactions for immune system funct...

Full description

Bibliographic Details
Main Authors: Craig McDonald, Vicky L. Morrison, David McGloin, Susanna Carola Fagerholm
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
LFA-1
kindlin-3
T cell
bond strength
ICAM-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.792813/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.792813/full

Similar Items