Genetic Study of Severe Prolonged Lymphopenia in Multiple Sclerosis Patients Treated With Dimethyl Fumarate

Genetic Study of Severe Prolonged Lymphopenia in Multiple Sclerosis Patients Treated With Dimethyl Fumarate

In delayed-release dimethyl fumarate (DMF)-treated patients, absolute lymphocyte count (ALC) often declines in the first year and stabilizes thereafter; early declines have been associated with development of severe prolonged lymphopenia (SPL). Prolonged moderate or severe lymphopenia is a known ris...

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Bibliographic Details
Main Authors: Dipen Sangurdekar, Chao Sun, Helen McLaughlin, Katherine Ayling-Rouse, Normand E. Allaire, Michelle A. Penny, Paola G. Bronson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
multiple sclerosis
lymphopenia
dimethyl fumarate
pharmacogenomics
transcriptomics
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01039/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01039/full

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