Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer’s disease

Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer’s disease

Alzheimer's disease (AD) is the most common cause of dementia. An early feature of the AD pathology is the dysregulation of intracellular Ca2+ signaling in neurons. In particular, increased Ca2+ release from endoplasmic reticulum-located Ca2+ channels, including inositol-1,4,5-trisphosphate typ...

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Bibliographic Details
Main Authors: D. Chernyuk, M. Callens, M. Polozova, A. Gordeev, M. Chigriai, A. Rakovskaya, A. Ilina, E. Pchitskaya, C. Van den Haute, T. Vervliet, G. Bultynck, I. Bezprozvanny
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:IBRO Neuroscience Reports
Subjects:
Alzheimer's disease
Ca2+ signaling
Bcl-2
Synaptic contacts
Amyloid plaques
5xFAD
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242123000155

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http://www.sciencedirect.com/science/article/pii/S2667242123000155

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