Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer

Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer

Abstract Background Excessive extracellular matrix (ECM) deposition in pancreatic ductal adenocarcinoma (PDAC) severely limits therapeutic drug penetration into tumors and is associated with poor prognosis. Collagen is the most abundant matrix protein in the tumor ECM, which is the main obstacle tha...

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Bibliographic Details
Main Authors: Xiao-Yan Yang, Jin-Guo Zhang, Qiao-Mei Zhou, Jie-Ni Yu, Yuan-Fei Lu, Xiao-Jie Wang, Jia-Ping Zhou, Xin-Fa Ding, Yong-Zhong Du, Ri-Sheng Yu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Nanobiotechnology
Subjects:
Tumor penetration
Extracellular matrix degradation
Biomimetic membrane
Photothermal therapy (PTT)
Photodynamic therapy (PDT)
CT imaging
Online Access:https://doi.org/10.1186/s12951-022-01738-6

Internet

https://doi.org/10.1186/s12951-022-01738-6

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