Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

To determine the role of cholesterol synthesis in pancreatic β-cells, a transgenic model of in vivo activation of sterol-regulatory element binding protein 2 (SREBP-2) specifically in β-cells (TgRIP-SREBP-2) was developed and analyzed. Expression of nuclear human SREBP-2 in β-cells resulted in sever...

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Bibliographic Details
Main Authors: Mayumi Ishikawa, Yuko Iwasaki, Shigeru Yatoh, Toyonori Kato, Shin Kumadaki, Noriyuki Inoue, Takashi Yamamoto, Takashi Matsuzaka, Yoshimi Nakagawa, Naoya Yahagi, Kazuto Kobayashi, Akimitsu Takahashi, Nobuhiro Yamada, Hitoshi Shimano
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Journal of Lipid Research
Subjects:
transcription factors
sterol-regulatory element binding protein
triglycerides
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520345843

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http://www.sciencedirect.com/science/article/pii/S0022227520345843

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