Differentiation-Inducing Factor-1 Suppresses the Expression of c-Myc in the Human Cancer Cell Lines

Differentiation-inducing factor-1 (DIF-1), a morphogen for Dictyostelium discoideum, inhibits the proliferation of human cancer cell lines by suppressing the Wnt/β-catenin signaling pathway. In this study, we examined the effect of DIF-1 on c-Myc, a target gene product of the Wnt/β-catenin signaling...

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Bibliographic Details
Main Authors: Kentaro Jingushi, Toshihisa Nakamura, Fumi Takahashi-Yanaga, Etsuko Matsuzaki, Yutaka Watanabe, Tatsuya Yoshihara, Sachio Morimoto, Toshiyuki Sasaguri
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319303858