The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway
As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2021-10-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.01097-21 |
| _version_ | 1818908059681947648 |
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| author | Ling Wang Mary E. A. Howell Ayrianna Sparks-Wallace Juan Zhao Culton R. Hensley Camri A. Nicksic Shanna R. Horne Kaylea B. Mohr Jonathan P. Moorman Zhi Q. Yao Shunbin Ning |
| author_facet | Ling Wang Mary E. A. Howell Ayrianna Sparks-Wallace Juan Zhao Culton R. Hensley Camri A. Nicksic Shanna R. Horne Kaylea B. Mohr Jonathan P. Moorman Zhi Q. Yao Shunbin Ning |
| author_sort | Ling Wang |
| collection | DOAJ |
| description | As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question. |
| first_indexed | 2024-12-19T22:05:00Z |
| format | Article |
| id | doaj.art-9062215602b446458b173e626e8fb19d |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-19T22:05:00Z |
| publishDate | 2021-10-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-9062215602b446458b173e626e8fb19d2022-12-21T20:04:04ZengAmerican Society for MicrobiologymBio2150-75112021-10-0112510.1128/mBio.01097-21The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic PathwayLing Wang0https://orcid.org/0000-0001-7861-2769Mary E. A. Howell1Ayrianna Sparks-Wallace2Juan Zhao3Culton R. Hensley4Camri A. Nicksic5Shanna R. Horne6Kaylea B. Mohr7Jonathan P. Moorman8Zhi Q. Yao9https://orcid.org/0000-0002-1333-1007Shunbin Ning10https://orcid.org/0000-0001-5484-5779Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USADepartment of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USAAs a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.https://journals.asm.org/doi/10.1128/mBio.01097-21 |
| spellingShingle | Ling Wang Mary E. A. Howell Ayrianna Sparks-Wallace Juan Zhao Culton R. Hensley Camri A. Nicksic Shanna R. Horne Kaylea B. Mohr Jonathan P. Moorman Zhi Q. Yao Shunbin Ning The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway mBio |
| title | The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway |
| title_full | The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway |
| title_fullStr | The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway |
| title_full_unstemmed | The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway |
| title_short | The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway |
| title_sort | ubiquitin sensor and adaptor protein p62 mediates signal transduction of a viral oncogenic pathway |
| url | https://journals.asm.org/doi/10.1128/mBio.01097-21 |
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