Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia

Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia

Abstract Age-related macular degeneration (AMD) is the most common blinding disease in the elderly population. However, there are still many uncertainties regarding the pathophysiology at the molecular level. Currently, impaired energy metabolism in retinal pigment epithelium (RPE) cells is discusse...

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Bibliographic Details
Main Authors: Yoshiyuki Henning, Katrin Willbrand, Safa Larafa, Gesa Weißenberg, Veronika Matschke, Carsten Theiss, Gina-Eva Görtz, Johann Matschke
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01695-5

Internet

https://doi.org/10.1038/s41420-023-01695-5

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