Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy

Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy

Optic nerve head (ONH) infarct can result in progressive retinal ganglion cell (RGC) death. The granulocyte colony-stimulating factor (GCSF) protects the RGC after ON infarct. However, protective mechanisms of the GCSF after ONH infarct are complex and remain unclear. To investigate the complex mech...

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Bibliographic Details
Main Authors: Rong-Kung Tsai, Keh-Liang Lin, Chin-Te Huang, Yao-Tseng Wen
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
rat anterior ischemic optic neuropathy model
retinal ganglion cell death
TBP associated factor 9
TP53 regulated inhibitor of apoptosis 1
transcriptome
Online Access:https://www.mdpi.com/1422-0067/23/15/8359

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https://www.mdpi.com/1422-0067/23/15/8359

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