Chelation of Theranostic Copper Radioisotopes with S-Rich Macrocycles: From Radiolabelling of Copper-64 to In Vivo Investigation

Chelation of Theranostic Copper Radioisotopes with S-Rich Macrocycles: From Radiolabelling of Copper-64 to In Vivo Investigation

Copper radioisotopes are generally employed for cancer imaging and therapy when firmly coordinated via a chelating agent coupled to a tumor-seeking vector. However, the biologically triggered Cu<sup>2+</sup>-Cu<sup>+</sup> redox switching may constrain the in vivo integrity o...

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Bibliographic Details
Main Authors: Marianna Tosato, Marco Verona, Chiara Favaretto, Marco Pometti, Giordano Zanoni, Fabrizio Scopelliti, Francesco Paolo Cammarata, Luca Morselli, Zeynep Talip, Nicholas P. van der Meulen, Valerio Di Marco, Mattia Asti
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
copper-64
chelators
radiopharmaceuticals
cancer
Online Access:https://www.mdpi.com/1420-3049/27/13/4158

Internet

https://www.mdpi.com/1420-3049/27/13/4158

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