Methanodibenzo[<i>b</i>,<i>f</i>][1,5]dioxocins as Novel Glutaminase Inhibitor with Anti-Glioblastoma Potential

Methanodibenzo[<i>b</i>,<i>f</i>][1,5]dioxocins as Novel Glutaminase Inhibitor with Anti-Glioblastoma Potential

Glutamine metabolism is an important hallmark of several cancers with demonstrated antitumor activity in glioblastoma cancer cells (GBM). GBM cells regulate glutamine and use it as a major energy source for their proliferation through the glutaminolysis process. Enzymes, such as glutaminase in gluta...

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Bibliographic Details
Main Authors: Akshaya Murugesan, Sana Kari, Anita Shrestha, Benedicta Assoah, Konda Mani Saravanan, Monica Murugesan, Ramesh Thiyagarajan, Nuno R. Candeias, Meenakshisundaram Kandhavelu
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
glutaminase inhibitors
new dioxocin derivatives
synthesis
characterization
signaling
interaction
Online Access:https://www.mdpi.com/2072-6694/15/4/1010

Internet

https://www.mdpi.com/2072-6694/15/4/1010

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