Methanodibenzo[<i>b</i>,<i>f</i>][1,5]dioxocins as Novel Glutaminase Inhibitor with Anti-Glioblastoma Potential
Glutamine metabolism is an important hallmark of several cancers with demonstrated antitumor activity in glioblastoma cancer cells (GBM). GBM cells regulate glutamine and use it as a major energy source for their proliferation through the glutaminolysis process. Enzymes, such as glutaminase in gluta...
Main Authors: | Akshaya Murugesan, Sana Kari, Anita Shrestha, Benedicta Assoah, Konda Mani Saravanan, Monica Murugesan, Ramesh Thiyagarajan, Nuno R. Candeias, Meenakshisundaram Kandhavelu |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-02-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/15/4/1010 |
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