Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1

Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1

Background and aims: Renal damage in severe coronavirus disease 2019 (COVID-19) is highly associated with mortality. Finding relevant therapeutic candidates that can alleviate it is crucial. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) have been shown to...

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Bibliographic Details
Main Authors: Shilin Zhou, Zanzhe Yu, Zihui Chen, Fengling Ning, Xuetao Hu, Tiangang Wu, Mingxue Li, Hong Xin, Svetlana Reilly, Xuemei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
olmesartan
HMGB1
SARS-CoV-2
envelope protein
renal fibrosis
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1187818/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1187818/full

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