Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A <italic toggle="yes">Streptococcus</italic>

Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A <italic toggle="yes">Streptococcus</italic>

ABSTRACT Streptococcus pyogenes (group A Streptococcus [GAS]) causes ~700 million human infections/year, resulting in >500,000 deaths. There is no commercial GAS vaccine available. The GAS surface protein arginine deiminase (ADI) protects mice against a lethal challenge. ADI is an enzyme that con...

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Bibliographic Details
Main Authors: Anna Henningham, Daniel J. Ericsson, Karla Langer, Lachlan W. Casey, Blagojce Jovcevski, G. Singh Chhatwal, J. Andrew Aquilina, Michael R. Batzloff, Bostjan Kobe, Mark J. Walker
Format: Article
Language:English
Published: American Society for Microbiology 2013-08-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00509-13

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https://journals.asm.org/doi/10.1128/mBio.00509-13

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