Reconstitution and NMR Characterization of the Ion-Channel Accessory Subunit Barttin in Detergents and Lipid-Bilayer Nanodiscs

Reconstitution and NMR Characterization of the Ion-Channel Accessory Subunit Barttin in Detergents and Lipid-Bilayer Nanodiscs

Barttin is an accessory subunit of ClC-K chloride channels expressed in the kidney and the inner ear. Main functions of ClC-K/barttin channels are the generation of the cortico-medullary osmotic gradients in the kidney and the endocochlear potential in the inner ear. Mutations in the gene encoding b...

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Bibliographic Details
Main Authors: Thibault Viennet, Stefanie Bungert-Plümke, Shantha Elter, Aldino Viegas, Christoph Fahlke, Manuel Etzkorn
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
barttin
ion channel
lipid bilayer nanodisc
detergent micelle
nuclear magnetic resonance
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00013/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00013/full

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