Dual Effects of Presynaptic Membrane Mimetics on α-Synuclein Amyloid Aggregation

Dual Effects of Presynaptic Membrane Mimetics on α-Synuclein Amyloid Aggregation

Aggregation of intrinsically disordered α-synuclein (αSN) under various conditions is closely related to synucleinopathies. Although various biological membranes have shown to alter the structure and aggregation propensity of αSN, a thorough understanding of the molecular and mechanical mechanism of...

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Bibliographic Details
Main Authors: Yuxi Lin, Dai Ito, Je Min Yoo, Mi Hee Lim, Wookyung Yu, Yasushi Kawata, Young-Ho Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
amyloid fibril
α-Synuclein
electrostatic interaction
helical structure
intermolecular interaction
membrane mimetic
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.707417/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.707417/full

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