Screening for DAX1/EWS‐FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma

Screening for DAX1/EWS‐FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma

Abstract Objective EWS‐FLI1 is the most common oncogenic fusion protein in Ewing's sarcoma family tumors (ESFTs). DAX1, an orphan member of the nuclear receptor superfamily, is up‐regulated by EWS‐FLI1 and plays a key role in the transformed phenotype of ESFTs. Methods To discover a functional...

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Bibliographic Details
Main Authors: Miwa Watanabe, Hiromichi Kosaka, Masamori Sugawara, Michihiro Maemoto, Yoko Ono, Takeshi Uemori, Ryota Shizu, Kouichi Yoshinari
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Cancer Medicine
Subjects:
DAX1
dihydroorotate dehydrogenase
Ewing's sarcoma
EWS‐FLI1
nucleotide pool
Online Access:https://doi.org/10.1002/cam4.5741

Internet

https://doi.org/10.1002/cam4.5741

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