Telomere Attrition in Induced Pluripotent Stem Cell-Derived Neurons From ALS/FTD-Related C9ORF72 Repeat Expansion Carriers

Telomere Attrition in Induced Pluripotent Stem Cell-Derived Neurons From ALS/FTD-Related C9ORF72 Repeat Expansion Carriers

The GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dysregulated DNA damage response and the generation of reactive oxygen species (ROS) have been postulated as major drivers of toxicity in C9ORF72 p...

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Bibliographic Details
Main Authors: Hayley Robinson, Sk Imran Ali, Martha Elena Diaz-Hernandez, Rodrigo Lopez-Gonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
induced pluripotent stem cells
motor neuron differentiation
telomeres
C9orf72
Amyotrophic lateral sclerosis, Frontotemporal dementia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.874323/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.874323/full

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