A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

Hybrid-based drugs linked through a transition metal constitute an emerging concept for <i>Plasmodium</i> intervention. To advance the drug design concept and enhance the therapeutic potential of this class of drugs, we developed a novel hybrid composed of quinolinic ligands amodiaquine...

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Manylion Llyfryddiaeth
Prif Awduron: Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D’Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M. Moreira, Nicoletta Basilico, David L. Williams, Miguel Prudêncio, Bruno Pradines, Maribel Navarro
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: MDPI AG 2022-06-01
Cyfres:Pharmaceutics
Pynciau:
malaria
<i>Plasmodium</i>
antimalarial drugs
quinolines
gold
heme detoxification
Mynediad Ar-lein:https://www.mdpi.com/1999-4923/14/6/1251

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https://www.mdpi.com/1999-4923/14/6/1251

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