Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice

Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice

The extracellular matrix (ECM) plays a key role in synaptogenesis and the regulation of synaptic functions in the central nervous system. Recent studies revealed that in addition to dopaminergic and serotoninergic neuromodulatory systems, microglia also contribute to the regulation of ECM remodeling...

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Bibliographic Details
Main Authors: Luisa Strackeljan, Ewa Baczynska, Carla Cangalaya, David Baidoe-Ansah, Jakub Wlodarczyk, Rahul Kaushik, Alexander Dityatev
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
extracellular matrix
synapses
parvalbumin
brevican
microglia
perineuronal nets
Online Access:https://www.mdpi.com/2073-4409/10/8/1862

Internet

https://www.mdpi.com/2073-4409/10/8/1862

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