Analytical challenges in estimating the effect of exposures that are bounded by follow-up time: experiences from the Blood Stream Infection—Focus on Outcomes study

Analytical challenges in estimating the effect of exposures that are bounded by follow-up time: experiences from the Blood Stream Infection—Focus on Outcomes study

Abstract Objective To illustrate the challenges of estimating the effect of an exposure that is bounded by duration of follow-up on all-cause 28-day mortality, whilst simultaneously addressing missing data and time-varying covariates. Study design and methods BSI-FOO is a multicentre cohort study wi...

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Bibliographic Details
Main Authors: Rebecca Evans, Katie Pike, Alasdair MacGowan, Chris A. Rogers
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Medical Research Methodology
Subjects:
Bloodstream infection
Mortality
Modifiable exposure
Time-varying covariates
Immortal time bias
Online Access:https://doi.org/10.1186/s12874-021-01393-9

Internet

https://doi.org/10.1186/s12874-021-01393-9

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