BMP2 genetically engineered MSCs and EPCs promote vascularized bone regeneration in rat critical-sized calvarial bone defects.

BMP2 genetically engineered MSCs and EPCs promote vascularized bone regeneration in rat critical-sized calvarial bone defects.

Current clinical therapies for critical-sized bone defects (CSBDs) remain far from ideal. Previous studies have demonstrated that engineering bone tissue using mesenchymal stem cells (MSCs) is feasible. However, this approach is not effective for CSBDs due to inadequate vascularization. In our previ...

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Bibliographic Details
Main Authors: Xiaoning He, Rosemary Dziak, Xue Yuan, Keya Mao, Robert Genco, Mark Swihart, Debanjan Sarkar, Chunyi Li, Changdong Wang, Li Lu, Stelios Andreadis, Shuying Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3614944?pdf=render

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http://europepmc.org/articles/PMC3614944?pdf=render

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