Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model

Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model

Abstract Impaired extinction of fear memory is one of the most common symptoms in post‐traumatic stress disorder (PTSD), with limited therapeutic strategies due to the poor understanding of its underlying neural substrates. In this study, functional screening is performed and identified hyperactivit...

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Bibliographic Details
Main Authors: Haoxiang Xiao, Kaiwen Xi, Kaifang Wang, Yongsheng Zhou, Baowen Dong, Jinyi Xie, Yuqiao Xie, Haifeng Zhang, Guaiguai Ma, Wenting Wang, Dayun Feng, Baolin Guo, Shengxi Wu
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
anterior cingulate cortex
fear extinction
Kv3.2
mediodorsal thalamus
parvalbumin interneuron
post‐traumatic stress disorder
Online Access:https://doi.org/10.1002/advs.202305939

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https://doi.org/10.1002/advs.202305939

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